Ribophorin I (IPR007676)

Short name: Ribophorin_I

Overlapping homologous superfamilies


Family relationships



Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC: OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are thought to be responsible for OST catalytic activity [PMID: 11443278]. Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function [PMID: 7720878]. Most family members are predicted to have a transmembrane helix at the C terminus of this region.

GO terms

Biological Process

GO:0006486 protein glycosylation

Molecular Function

GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Cellular Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.