Domain

Selenoprotein P, C-terminal (IPR007672)

Short name: SelP_C

Domain relationships

None.

Description

SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [PMID: 10775431]. It is thought to be glycosylated [PMID: 11168591]. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity [PMID: 10775431]. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage [PMID: 11168591]. The promoter structure of bovine SelP suggests that it may be involved in countering heavy metal intoxication, and may also have a developmental function [PMID: 9358058]. The N-terminal region always contains one Sec residue, and this is separated from the C-terminal region (9-16 sec residues) by a histidine-rich sequence [PMID: 11168591]. The large number of Sec residues in the C-terminal portion of SelP suggests that it may be involved in selenium transport or storage. However, it is also possible that this region has a redox function [PMID: 11168591].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam