Hypoxia induced protein, domain (IPR007667)

Short name: Hypoxia_induced_domain

Overlapping homologous superfamilies


Domain relationships



The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of the microenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It is predicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loop across the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. The predicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [PMID: 15968589, PMID: 16815968]. The profile we developed covers the predicted TMH and loop regions.

This domain is found in proteins thought to be involved in the response to hypoxia [PMID: 11172064]. It is also found in altered inheritance of mitochondria proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles