Family

ATPase inhibitor, IATP, mitochondria (IPR007648)

Short name: ATPase_inhibitor_IATP_mt

Family relationships

None.

Description

ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [PMID: 12186878] ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP [PMID: 8961923]. The minimum inhibitory region for bovine inhibitor (P01096) is from residues 39 to 72 [PMID: 8961923]. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH , the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity [PMID: 12186878].

GO terms

Biological Process

GO:0045980 negative regulation of nucleotide metabolic process

Molecular Function

GO:0004857 enzyme inhibitor activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam