Family

Mitochondrial ATPase inhibitor (IPR007648)

Short name: ATPase_inhibitor_mt

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [PMID: 12186878] ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP [PMID: 8961923]. The minimum inhibitory region for bovine inhibitor (P01096) is from residues 39 to 72 [PMID: 8961923]. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH , the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity [PMID: 12186878].

GO terms

Biological Process

GO:0032780 negative regulation of ATPase activity

Molecular Function

GO:0042030 ATPase inhibitor activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam