Conserved Site

Glycosyltransferase, DXD sugar-binding motif (IPR007577)

Short name: GlycoTrfase_DXD_sugar-bd_CS

Description

This entry represents those sugar-binding regions of glycosyltransferases that contain a DXD motif. The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases [PMID: 9653120].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam