Mid2 domain (IPR007567)

Short name: Mid2_dom

Overlapping homologous superfamilies


Domain relationships



This domain is found near the C terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress. The C-terminal cytoplasmic region of Mid2 is known to interact with Rom2, a guanine nucleotide exchange factor (GEF) for Rho1, which is part of the cell wall integrity signalling pathway [PMID: 11113201].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.