InterPro

This entry includes PINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity. They share a similar domain organisation with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes.

RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control [PMID: 11096100]. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum(ER) to the Golgi complex in interphase cells [PMID: 11096100, PMID: 16600870, PMID: 16571679].

Tip20 is involved in the retrograde transport from the Golgi to the ER [PMID: 19151722, PMID: 8334998].

Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants [PMID: 17194767].