NDUFAF3/Mth938 domain-containing protein (IPR007523)

Short name: NDUFAF3/AAMDC

Overlapping homologous superfamilies

Family relationships


This entry includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) [PMID: 19463981], and the Mth938 domain-containing protein [PMID: 22279136]. The crystal structure of NDUFAF3 revealed a 3-layer beta+alpha/beta/alpha topology [PMID: 11746696].

NADH:ubiquinone oxidoreductase (complex I) (EC: is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.