Domain

Bul1, N-terminal (IPR007519)

Short name: Bul1_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is the N terminus of Saccharomyces cerevisiae (Baker's yeast) Bul1 and Bul2. Bul1 binds the ubiquitin ligase Rsp5, via an N-terminal PPSY motif (157-160 in P48524) [PMID: 9931424]. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1 [PMID: 11500494], degradation of Rog1 in cooperation with Bul2 and GSK-3 [PMID: 10958669], and mitochondrial inheritance [PMID: 10366593]. Bul2, which is homologous to Bul1, also interacts with Rsp5 [PMID: 9931424].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam