Domain

LytTR DNA-binding domain (IPR007492)

Short name: LytTR_DNA-bd_dom

Domain relationships

None.

Description

The LytTR domain is a DNA-binding, potential winged helix-turn-helix (wHTH) domain of about 100 amino acids, present in bacterial transcriptional regulators of the algR/agrA/lytR family. It is named after Bacillus subtilis LytT and Staphylococcus aureus lytR response regulators, involved in the regulation of cell autolysis [PMID: 12034833].

The LytTR domain is found in several bacterial cytoplasmic proteins that regulate the production of important virulence factors, like extracellular polysaccharides, toxins and bacteriocins. These response regulators of the microbial two-component signal transduction systems contain N-terminal cheY-like domains and the LytTR domain in the C-terminal part is expected to bind to specific DNA sequences in the upstream regions of target genes [PMID: 12367524]. Other domains found N-terminally of LytTR are an ATP-binding domain of ABC-type transporter family and a PAS domain. Besides these cytoplasmic proteins, LytTR also occurs in membrane-bound bacterial proteins. The N-terminal parts of these proteins contain three to eight predicted transmembrane segments or the transmembrane MHYT domain.

According to secondary structure predictions the LytTR domain consists of four beta-strands and three alpha-helices. The structure is predicted to form a novel type of DNA-binding domain, showing similarity to the 'winged HTH' or 'winged helix' proteins [PMID: 12034833, PMID: 12367524].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
PROSITE profiles