Domain

Arginine-tRNA-protein transferase, C-terminal (IPR007472)

Short name: Arg-tRNA-P_Trfase_C

Domain relationships

None.

Description

Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [PMID: 9858543]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity [PMID: 7495814]. Of these, only Cys 94 appears to be completely conserved in this family.

This entry represents the C-terminal region of the enzyme arginine-tRNA-protein transferase, found in both eukaryotic and prokaryotic enzymes.

GO terms

Biological Process

GO:0016598 protein arginylation

Molecular Function

GO:0004057 arginyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam