DNA polymerase III chi subunit, HolC (IPR007459)

Short name: DNA_pol3_chi

Overlapping homologous superfamilies

Family relationships



The DNA polymerase III holoenzyme (EC: is the polymerase responsible for the replication of the Escherichia coli chromosome. The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either the tau or gamma product of gene dnax, complexed to and to chi psi. Chi forms a 1:1 heterodimer with psi. The chi psi complex functions by increasing the affinity of tau and gamma for allowing a functional clamp-loading complex to form at physiological subunit concentrations. Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi [PMID: 7494000].

GO terms

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.