Family

Serglycin (IPR007455)

Short name: Serglycin

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Serglycin was first identified as an intracellular proteoglycan expressed by hematopoietic cells. All inflammatory cells highly synthesize serglycin and store it in granules, where it interacts with numerous inflammatory mediators, such as proteases, chemokines, cytokines, and growth factors. Later serglycin was found to be expressed by various non-hematopoietic cell types, such as tumour cells. Serglycin promotes the aggressive phenotype of tumours and confers resistance against drugs and complement system attack [PMID: 24455486].

Human serglycin consists of a small core protein containing eight serine/glycine repeats. Each serine of this repeat region is a potential GAG attachment site [PMID: 20807648].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam