Domain

ZipA, C-terminal FtsZ-binding domain (IPR007449)

Short name: ZipA_FtsZ-bd_C

Domain relationships

None.

Description

This entry represents the ZipA C-terminal domain. ZipA, a membrane-anchored protein, is an essential cell division protein involved in septum formation [PMID: 9008158, PMID: 9864327]. FtsA and the C-terminal domain of ZipA bind FtsZ, a homologue of eukaryotic tubulins and a major component of the bacterial septal ring [PMID: 10209756], at the prospective division site. This is followed by the sequential addition of FtsK, FtsQ, FtsL, FtsW, FtsI, and FtsN [PMID: 11163134,PMID: 11948172,PMID: 11847116]. ZipA contains three domains: a short N-terminal membrane-anchored domain, a central P/Q domain that is rich in proline and glutamine and a C-terminal domain, which comprises almost half the protein. The structure of the C-terminal domain is an alpha-beta fold with three alpha helices and a beta sheet of six antiparallel beta strands. The major loops protruding from the beta sheet surface are thought to form a binding site for FtsZ [PMID: 10924108], .

GO terms

Biological Process

GO:0090529 cell septum assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SMART
SUPERFAMILY
ProDom
CDD
Pfam