Domain

Thiamin pyrophosphokinase, vitamin B1-binding domain (IPR007373)

Short name: Thiamin_PyroPKinase_B1-bd

Domain relationships

None.

Description

Thiamin pyrophosphokinase (TPK, EC:2.7.6.2) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [PMID: 11435118].

GO terms

Biological Process

GO:0009229 thiamine diphosphate biosynthetic process

Molecular Function

GO:0030975 thiamine binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
SMART
Pfam
GENE3D