Thiamin pyrophosphokinase, catalytic domain (IPR007371)

Short name: TPK_catalytic

Overlapping homologous superfamilies

Domain relationships



Thiamin pyrophosphokinase (TPK, EC: catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggests that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [PMID: 11435118].

GO terms

Biological Process

GO:0009229 thiamine diphosphate biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0004788 thiamine diphosphokinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.