Pathways & interactions
tRNA (guanine-N1-)-methyltransferase, eukaryotic (IPR007356)
Short name: tRNA_m1G_MeTrfase_euk
Overlapping homologous superfamilies
- tRNA (guanine-N1-)-methyltransferase, eukaryotic (IPR007356)
- tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A (IPR016653)
- tRNA methyltransferase 10 homolog C (IPR025812)
In transfer RNA many different modified nucleosides are found, especially in the anticodon region.
tRNA (guanine-N1-)-methyltransferase EC:188.8.131.52 is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction:
The mechanism of the trmD3-induced frameshift involving mutant tRNA(Pro) and tRNA(Leu) species has been investigated [PMID: 7689113]. It has been suggested that the conformation of the anticodon loop may be a major determining element for the formation of m1G37 in vivo [PMID: 9047363].
- PTHR13563 (PTHR13563)