Family

tRNA (guanine-N1-)-methyltransferase, eukaryotic (IPR007356)

Short name: tRNA_m1G_MeTrfase_euk

Family relationships

Description

In transfer RNA many different modified nucleosides are found, especially in the anticodon region. tRNA (guanine-N1-)-methyltransferase EC:2.1.1.31 is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction: S-adenosyl-L-methionine + tRNA -> S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine methylating guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons. The presence of m1G improves the cellular growth rate and the polypeptide steptime and also prevents the tRNA from shifting the reading frame [PMID: 2207153].

The mechanism of the trmD3-induced frameshift involving mutant tRNA(Pro) and tRNA(Leu) species has been investigated [PMID: 7689113]. It has been suggested that the conformation of the anticodon loop may be a major determining element for the formation of m1G37 in vivo [PMID: 9047363].

Family member HYNA is the product of a novel gene expressed in human liver cancer tissue.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER