Endonuclease I (IPR007346)

Short name: Endonuclease-I

Overlapping homologous superfamilies


Family relationships



Bacterial periplasmic or secreted (EC: Escherichia coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species. It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown [PMID: 7867949]. Other family members are known to be extracellular [PMID: 3036665]. This family also includes a non-specific, Mg2+-activated ribonuclease precursor (Q03091) [PMID: 1396690].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004518 nuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.