Family

TIP41-like protein (IPR007303)

Short name: TIP41-like

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

In budding yeast, TIP41 interacts with TAP42 to regulate protein phosphatase activity [PMID: 11741537]. In mammalian cells, TIP41-like protein (TIPRL) does not directly bind TAP42, but rather primarily interacts with PP2A, PP4 or PP6 catalytic subunits. TIPRL inhibits PP4 activity to allow for H2AX phosphorylation and the subsequent DNA damage response [PMID: 26717153].

GO terms

Biological Process

GO:0043666 regulation of phosphoprotein phosphatase activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER