Copper resistance lipoprotein NlpE (IPR007298)

Short name: Cu-R_lipoprotein_NlpE

Overlapping homologous superfamilies


Family relationships



This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [PMID: 11830644]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. NlpE from Escherichia coli and Salmonella typhi is also known to confer copper tolerance in copper-sensitive strains of E. coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [PMID: 7635807].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.