Inclusion membrane protein A (IPR007285)

Short name: Inclusion_membr-A

Overlapping homologous superfamilies


Family relationships



Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is nonfusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA (Inclusion membrane protein A), is functionally associated with the homotypic fusion of inclusions [PMID: 12065525]. This family probably includes members of the wider Inc family rather than just IncA. Members are usually either 2 or 4TM proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.