Domain

Mre11, DNA-binding (IPR007281)

Short name: Mre11_DNA-bd

Domain relationships

None.

Description

The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication [PMID: 11988766]. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [PMID: 10823903].

GO terms

Biological Process

GO:0006302 double-strand break repair

Molecular Function

GO:0004519 endonuclease activity
GO:0030145 manganese ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam