Ctr copper transporter (IPR007274)

Short name: Cop_transporter

Overlapping homologous superfamilies


Family relationships



The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionines probably coordinate copper during the process of metal transport.

GO terms

Biological Process

GO:0035434 copper ion transmembrane transport

Molecular Function

GO:0005375 copper ion transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.