Isoprenylcysteine carboxyl methyltransferase (IPR007269)

Short name: ICMT_MeTrfase

Overlapping homologous superfamilies


Family relationships


The isoprenylcysteine o-methyltransferase (EC: carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae, this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology [PMID: 11451995].

GO terms

Biological Process

GO:0006481 C-terminal protein methylation

Molecular Function

GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.