Endoplasmic reticulum oxidoreductin 1 (IPR007266)

Short name: Ero1

Overlapping homologous superfamilies


Family relationships



This entry represents endoplasmic oxidoreductin-1 (Ero1) from yeast and its homologues from mammals, Ero1-Lalpha and Ero1-Lbeta. Ero1 is an essential oxidoreductase that oxidises proteins in the endoplasmic reticulum to produce disulfide bonds [PMID: 10754564, PMID: 10982384, PMID: 22412017]. The activity of Ero1 is regulated by Pdi1, which is a protein disulfide isomerase. This regulation of Ero1 through reduction and oxidation of regulatory bonds within Ero1 is essential for maintaining the proper redox balance in the ER [PMID: 22412017, PMID: 18971943].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0003756 protein disulfide isomerase activity

Cellular Component

GO:0005783 endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.