GPI transamidase component PIG-T (IPR007245)

Short name: PIG-T

Overlapping homologous superfamilies


Family relationships



Phosphatidylinositol-glycan biosynthesis class T protein (PIG-T, also known as Gpi16 in budding yeasts) is a component of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [PMID: 11598210]. Mammalian GPI transamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for its function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear [PMID: 14660601].

GO terms

Biological Process

GO:0016255 attachment of GPI anchor to protein

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0042765 GPI-anchor transamidase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.