Family

Autophagy-related protein 17 (IPR007240)

Short name: Atg17

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p. It is found in the vacuole [PMID: 11689437]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Auotphagy protein 16 (Atg16) has been shown to be bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate [PMID: 10406794]. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [PMID: 10712513].

Autophagy protein 17 (Atg17) forms complex with Atg29 and Atg31, and this complex is critical for both PAS (preautophagosomal structure) formation and autophagy [PMID: 23219485]. This entry also contains Arabidopsis autophagy protein 11 (Atg11), which is an important modulator of the ATG1-ATG13 complex and a multifunctional scaffold required for bulk autophagy and the selective clearance of mitochondria [PMID: 24991832].

GO terms

Biological Process

GO:0006914 autophagy

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam