DNA primase large subunit, eukaryotic/archaeal (IPR007238)

Short name: DNA_primase_lsu_euk/arc

Family relationships


DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast Saccharomyces cerevisiae) [PMID: 2528682]. Both subunits participate in the formation of the active site, but the ATP binding site is located on the small subunit [PMID: 2023935]. Primase function has also been demonstrated for human and mouse primase subunits [PMID: 8026492].

GO terms

Biological Process

GO:0006269 DNA replication, synthesis of RNA primer

Molecular Function

GO:0003896 DNA primase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.