YbaK/aminoacyl-tRNA synthetase-associated domain (IPR007214)

Short name: YbaK/aa-tRNA-synth-assoc-dom

Overlapping homologous superfamilies

Domain relationships



Bacterial prolyl-tRNA synthetases and some smaller paralogues, YbaK and ProX, can hydrolyse misacylated Cys-tRNA(Pro) or Ala-tRNA(Pro) [PMID: 15886196]. The small bacterial protein Ybak preferentially hydrolyses Cys-tRNA(Pro) and Cys-tRNA(Cys) [PMID: 15886196, PMID: 23185990]. ProX functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro) [PMID: 14663147]. Prolyl-tRNA synthetases main function is to catalyse the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) [PMID: 10642548].

This entry represents a domain characteristic of Ybak and ProX, that can also be found with other domains in prolyl-tRNA synthetases.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0002161 aminoacyl-tRNA editing activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.