Methyltransferase Ppm1/Ppm2/Tcmp (IPR007213)

Short name: Ppm1/Ppm2/Tcmp

Overlapping homologous superfamilies

Family relationships


This entry includes a group of methyltransferases such as leucine carboxyl methyltransferase 1 (known as Ppm1 in yeast and LCMT1 in mammals), leucine carboxyl methyltransferase 2 (Ppm2/LCMT2) and O-methyltransferase TcmP.

Ppm1 regulates the activity of serine/threonine phosphatase 2A (PP2A) through methylation of the C-terminal leucine residue of the catalytic subunit of PP2A [PMID: 10600115, PMID: 11697862, PMID: 11060018]. This affects the heteromultimeric composition of PP2A which in turn affects protein recognition and substrate specificity. Like many other methyltransferases Ppm1 uses S-adenosylmethionine (SAM) as the methyl donor. Ppm1 contains the common SAM-dependent methyltransferase core fold, with various insertions and additions creating a specific PP2A binding site [PMID: 14660564]. Ppm2, a homologue of Ppm1, is a S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway, which is part of tRNA modification [PMID: 16642040].

Streptomyces glaucescens TcmP is an O-methyltransferase that catalyses the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2, which is then further processed to produce the antibiotic TCM C [PMID: 11009387].

GO terms

Biological Process

GO:0032259 methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.