Domain

Radical SAM (IPR007197)

Short name: rSAM

Domain relationships

Description

Radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S centre [PMID: 11222759, PMID: 15317939].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam