Domain

Up-frameshift suppressor 2 (IPR007193)

Short name: Up-fram_suppressor-2

Domain relationships

None.

Description

This entry represents Up-frameshift suppressor 2 (also known as Nonsense-mediated mRNA decay protein 2). Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay [PMID: 11073994].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam