Family

Archaeal transcription elongation factor Spt4 (IPR007178)

Short name: Spt4_arch

Family relationships

None.

Description

DNA-directed RNA polymerases,also known as DNA-dependent RNA polymerases, are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. Eukaryotes have three different DNA-directed RNA polymerases (RNAPs), Pol I, II, and III, whereas Archaea and Bacteria have single enzymes.

RNAPs are multisubunit enzymes. Archaeal RNAP is closely related to eukaryotic RNAP II [PMID: 19880312], which consists of 12 subunits. Archaeal RNAP has an additional subunit, Rpo13, with no orthologue in the eukaryotic enzyme [PMID: 19419240].

In Sulfolobus acidocaldarius, Spt4 (also known as RpoE2) is one of 13 subunits in the RNA polymerase. RpoE2 in Methanocaldococcus jannaschii (Methanococcus jannaschii) contains a predicted C4-type zinc finger at positions 4 to 19 and this sequence has been noted as a potential metal binding motif in S. acidocaldarius [PMID: 8127719]. It is therefore possible that family members contain a C4 zinc finger.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
HAMAP