Archaeal transcription elongation factor Spt4 (IPR007178)

Short name: Spt4_arch

Overlapping homologous superfamilies

Family relationships



DNA-directed RNA polymerases,also known as DNA-dependent RNA polymerases, are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. Eukaryotes have three different DNA-directed RNA polymerases (RNAPs), Pol I, II, and III, whereas Archaea and Bacteria have single enzymes.

RNAPs are multisubunit enzymes. Archaeal RNAP is closely related to eukaryotic RNAP II [PMID: 19880312], which consists of 12 subunits. Archaeal RNAP has an additional subunit, Rpo13, with no orthologue in the eukaryotic enzyme [PMID: 19419240].

In Sulfolobus acidocaldarius, Spt4 (also known as RpoE2) is one of 13 subunits in the RNA polymerase. RpoE2 in Methanocaldococcus jannaschii (Methanococcus jannaschii) contains a predicted C4-type zinc finger at positions 4 to 19 and this sequence has been noted as a potential metal binding motif in S. acidocaldarius [PMID: 8127719]. It is therefore possible that family members contain a C4 zinc finger.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.