SpoVT-AbrB domain (IPR007159)

Short name: SpoVT-AbrB_dom

Overlapping homologous superfamilies

Domain relationships

  • SpoVT-AbrB domain (IPR007159)


The SpoVT-AbrB domain is a DNA-binding domain found in a large protein superfamily [PMID: 16223496, PMID: 15939023], which includes:

  • Bacterial antibiotic resistance protein B (AbrB), a transition-state regulator.
  • Bacterial SpoVT, a late sporulation factor that modulates forespore-specific sigma G-dependent transcription.
  • Bacterial PrlF, an antitoxin component of a toxin-antitoxin (TA) module.
  • Bacterial transcription factors (antitoxins) of plasmid maintenance systems (VapB, MvpT, VppA ,VagC, PemI, MazE, ChpS).
  • Bacterial transcriptional regulator MraZ, involved in the expression of the division and cell wall (dcw) cluster. It contains two copies of the SpoVT-AbrB domain.
  • Bacterial endoribonuclease SymE.
  • Sulfolobus solfataricus repressor-like proteins SSo7c3 and SSo7c4.

The SpoVT-AbrB domain contains four beta strands and one alpha helix and can be described as a pair of beta hairpins linked by the alpha helix [PMID: 16223496, PMID: 15939023].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles