Microtubule-associated protein, MAP65/Ase1/PRC1 (IPR007145)
Short name: MAP65_Ase1_PRC1
Overlapping homologous superfamilies
- Microtubule-associated protein, MAP65/Ase1/PRC1 (IPR007145)
- Protein regulator of cytokinesis 1 (IPR032921)
This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals.
MAP65-1 plays a role in stabilising anti-parallel microtubules in the central spindle at anaphase to early cytokinesis. MAP65-1 is cell cycle regulated by phosphorylation [PMID: 16014384, PMID: 15908607, PMID: 16098102, PMID: 17011227, PMID: 16847052].
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone [PMID: 12082078]. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [PMID: 20691902, PMID: 9885575]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [PMID: 15297875, PMID: 15625105, PMID: 16431929] and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [PMID: 19468300].
- PTHR19321 (PTHR19321)