RNA polymerase II associated factor Paf1 (IPR007133)

Short name: RNA_pol_II-assoc_Paf1

Overlapping homologous superfamilies


Family relationships



In budding yeasts, Paf1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1 [PMID: 11884586]. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [PMID: 20178742].

This entry also includes Paf1 homologues from animals and plants. Human Paf1, also known as PD2 (pancreatic differentiation 2), is associated with tumorigenesis [PMID: 16491129]. Human Paf1 complex (Paf1C) consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications [PMID: 1913663]. Human Paf1 complex has a crucial role in the antiviral response [PMID: 22419161].

Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time [PMID: 21799800].

GO terms

Biological Process

GO:0016570 histone modification
GO:0006368 transcription elongation from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016593 Cdc73/Paf1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.