Pathways & interactions
LicD family (IPR007074)
Short name: LicD_fam
Overlapping homologous superfamilies
- LicD family (IPR007074)
- Fukutin-related (IPR009644)
The LicD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [PMID: 10200966]. These proteins are part of the nucleotidyltransferase superfamily [PMID: 19833706].
Fukutin, which is a member of the LicD family, is a human protein which may be involved in the modification of glycan moieties of alpha-dystroglycan; defects in Fukutin are associated with congential muscular dystrophy [PMID: 11445638].
- PF04991 (LicD)