Family

LicD family (IPR007074)

Short name: LicD_fam

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The LicD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [PMID: 10200966]. These proteins are part of the nucleotidyltransferase superfamily [PMID: 19833706].

Fukutin, which is a member of the LicD family, is a human protein which may be involved in the modification of glycan moieties of alpha-dystroglycan; defects in Fukutin are associated with congential muscular dystrophy [PMID: 11445638].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam