Surfeit locus 6 (IPR007019)

Short name: SURF6

Overlapping homologous superfamilies


Family relationships



This entry represents the surfeit locus protein SURF6 from mammals and its homologues from plants and fungi.

In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [PMID: 9548374]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein.

Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity [PMID: 15629442]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [PMID: 17272295, PMID: 17804645].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.