Family

DNA polymerase V/Myb-binding protein 1A (IPR007015)

Short name: DNA_pol_V/MYBBP1A

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Proteins of this family are predominantly nucleolar. Myb-binding protein 1A (MYBBP1A) is a transcription regulator that may play an important role in the cellular stress response [PMID: 11956195, PMID: 19129230, PMID: 24375404]. This family also includes the fifth essential DNA polymerase (Pol5p) of Schizosaccharomyces pombe (Fission yeast) and Saccharomyces cerevisiae (Baker's yeast) (EC:2.7.7.7). Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units [PMID: 12093911]. Despite its name, Pol5 is unrelated to any known polymerase. Both Pol5p and MYBBP1A are thought to function as regulators of rDNA transcription, and may have other functions [PMID: 12695662].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0008134 transcription factor binding

Cellular Component

GO:0005730 nucleolus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam