Family

SH3-binding, glutamic acid-rich protein (IPR006993)

Short name: Glut_rich_SH3-bd

Family relationships

None.

Description

This family of proteins, which contains SH3BGRL3, is functionally uncharacterised. SH3BGRL3 is a highly conserved small protein, which is widely expressed and shows a significant similarity to glutaredoxin 1 (GRX1) of Escherichia coli which is predicted to belong to the thioredoxin superfamily. However, SH3BGRL3 lacks both conserved cysteine residues, which characterise the enzymatic active site of GRX. This structural feature raises the possibility that SH3BGRL3 and its homologues could function as endogenous modulators of GRX activity [PMID: 11444877].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
Pfam