Uso1/p115-like vesicle tethering protein, C-terminal (IPR006955)

Short name: Uso1_p115_C

Overlapping homologous superfamilies


Domain relationships



This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein. This myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [PMID: 11927603]. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the Golgi stack. This domain is found in the acidic C-terminal region, which binds to the golgins giantin and GM130. p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another [PMID: 12077354].

GO terms

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

GO:0008565 protein transporter activity

Cellular Component

GO:0005737 cytoplasm
GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.