Vesicle tethering protein Uso1/P115-like , head domain (IPR006953)

Short name: Vesicle_Uso1_P115_head

Overlapping homologous superfamilies

Domain relationships



This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associated protein (TAP) or Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [PMID: 11927603]. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the Golgi stack. This domain is found in the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering [PMID: 11927603]. The N-terminal part of the head region contains context-detected Armadillo/beta-catenin-like repeats.

GO terms

Biological Process

GO:0006886 intracellular protein transport
GO:0048280 vesicle fusion with Golgi apparatus

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000139 Golgi membrane
GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.