Family

Retinal cGMP phosphodiesterase, gamma subunit (IPR006952)

Short name: PDE6_gamma

Overlapping homologous superfamilies

Family relationships

None.

Description

Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit [PMID: 11900530], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells [PMID: 11502744].

GO terms

Biological Process

GO:0007601 visual perception

Molecular Function

GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0030553 cGMP binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF
Pfam