Family

SNF5/SMARCB1/INI1 (IPR006939)

Short name: SNF5

Family relationships

Description

SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterised so far [PMID: 10325430]. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex [PMID: 11390659]. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs) [PMID: 9671307].

GO terms

Biological Process

GO:0006338 chromatin remodeling

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000228 nuclear chromosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER