HAP1, N-terminal (IPR006933)

Short name: HAP1_N

Domain relationships



This entry represents a N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntingtons disease is unclear [PMID: 7477378, PMID: 9599014, PMID: 9285789]. This domain also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34 [PMID: 11161814].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.