Domain

Glutathione-dependent formaldehyde-activating enzyme/centromere protein V (IPR006913)

Short name: GFA/CENP-V

Overlapping homologous superfamilies

Domain relationships

None.

Description

Glutathione-dependent formaldehyde-activating enzyme Gfa catalyses the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione [PMID: 11741920]. Gfa has a new fold with two zinc-sulphur centres, one that is structural and one catalytic [PMID: 15548539]. This domain is also found in centromere protein V, a kinetochore protein related to Gfa [PMID: 18772885].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016846 carbon-sulfur lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam