Pathways & interactions
Flavin-dependent halogenase (IPR006905)
Short name: Flavin_halogenase
Overlapping homologous superfamilies
- FAD/NAD(P)-binding domain superfamily (IPR036188)
- Flavin-dependent halogenase (IPR006905)
- Flavin-dependent tryptophan halogenase (IPR033856)
This family consists of tryptophan halogenases from bacteria and related halogenases from eukaryotes such as fungi and Dictyostelium [PMID: 20231486].
The bacterial flavin-dependent tryptophan halogenase PrnA catalyses the chlorination of tryptophan to form 7-chlorotryptophan [PMID: 16195462].
The halogenase gsfI of Penicillium aethiopicum is required for the biosynthesis of the antifungal griseofulvin, a drug used to treat dermatophyte infections. Halogenase gsfI chlorinates the intermediate compound griseophenone C to former another intermediate, griseophenone B [PMID: 23978092]. Sulochrin halogenase from Aspergillus terreus converts sulochrin to dihydrogeodin, a step in the biosynthesis of geodin [PMID: 24009710].
- PF04820 (Trp_halogenase)