Domain

Hepatocyte nuclear factor 1, N-terminal (IPR006899)

Short name: HNF-1_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence [PMID: 1988016] and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [PMID: 9133564].

GO terms

Biological Process

GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam