Hepatocyte nuclear factor 1, beta isoform, C-terminal (IPR006897)

Short name: HNF1b_C

Overlapping homologous superfamilies


Domain relationships



This domain consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription [PMID: 7900999]. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [PMID: 9133564].

GO terms

Biological Process

GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.