Sec23/Sec24, trunk domain (IPR006896)

Short name: Sec23/24_trunk_dom

Overlapping homologous superfamilies

Domain relationships



COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [PMID: 11535824]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation [PMID: 12239560].

Sec23 p and Sec24p are structurally related, folding into five distinct domains: a beta-barrel, a zinc-finger (IPR006895), an alpha/beta trunk domain, an all-helical region (IPR006900), and a C-terminal gelsolin-like domain (IPR007123). This entry describes the Sec23/24 alpha/beta trunk domain, which is formed from a single, approximately 250-residue segment plugged into the beta-barrel between strands beta-1 and beta-19. The trunk has an alpha/beta fold with a vWA topology, and it forms the dimer interface, primarily involving strand beta-14 on Sec23 and Sec24; in addition, the trunk domain of Sec23 contacts Sar1.

GO terms

Biological Process

GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006886 intracellular protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030127 COPII vesicle coat

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.